Morphological features of complicated gastroduodenal ulcers

نویسندگان

چکیده

The objective of the study was to evaluate structural changes in margin gastroduodenal ulcers complicated by perforation, bleeding or penetration terms features ulcer healing. Methods and materials . Histological IHC studies were performed on 25 patients main group with perforated 23 control chronic recurrent penetration. sections stained hematoxylin eosin, Van Gieson's picrofuchsin. Immunohistochemical reactions antibodies Ki-67, CD68, CD138, CD34. Results On macroscopic evaluation, a clear even perforation noted. examination background acute dyscirculatory clearly shows zone necrosis weakly expressed layer granulation tissue, which majority cases practically absent. consists minimally presented, delimited tissue detritus unchanged muscle layer. Plasma cells dominated cell infiltrate, index proliferative activity epithelium margins about 45 %, distributed fairly evenly. Conclusions Perforated can be considered as special most pronounced infiltration plasmatic eosinophils, edema changes, uniform high epithelium. Changes allow for complete regeneration without excessive scarring precise suturing perforation.

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ژورنال

عنوان ژورنال: U?enye Zapiski Sankt-Peterburgskogo Gosudarstvennogo Medicinskogo Universiteta im. Akad. I.P. Pavlova

سال: 2022

ISSN: ['2541-8807', '1607-4181']

DOI: https://doi.org/10.24884/1607-4181-2022-29-1-54-62